Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) yindlela engaqhelekanga yokusabela kwesikhumba kwi-90% yamatyala anxulumene nokulawulwa kweyeza. Acute generalized exanthematous pustulosis ibonakala ngogqabhuko-dubulo lwesikhumba olubonakala ngokomyinge weentsuku ezintlanu emva kokuba iyeza liqalisiwe. Olu gqabhuko luyi-pustules, oko kukuthi ukuqhuma okumhlophe okubomvu okanye okubomvu kwesikhumba esiqulethe izinto ezinamafu okanye ezihlambulukileyo (ubovu). Izilonda zolusu zihlala zisonjululwa phakathi kweentsuku ezi-1-3 zokuyeka amayeza awonayo.
☆ Kwiziphumo zika-2022 ze-Stiftung Warentest ezivela eJamani, ukwaneliseka kwabathengi ngeModelDerm bekungaphantsi kancinci kunokubonisana nge-telemedicine ehlawulweyo.
Izilonda ezixhaphakileyo kunye ne-erythema kunye ne-pustules zivela ngokukhawuleza.
References
Acute generalized exanthematous pustulosis (AGEP) kukusabela kolusu oluphawulwe ngamaqhuma amancinci, azaliswe bubofu kwisiseko solusu olubomvu. Ngokuqhelekileyo kwenzeka xa umntu ethatha amayeza athile, njenge-antibiotics, kwaye ngokukhawuleza asasazeka kuwo wonke umzimba. Emva kokuyeka amayeza okuqala, iimpawu zihlala ziphela kwiiveki ezimbini, zihlala zishiya ukuphalala kwesikhumba. Nangona iqhelekile ukuba ayimandundu kwaye iphelele eluswini, iimeko ezimandundu zinokudityaniswa kunye nezinye izenzo ezimandundu zolusu njenge Stevens-Johnson syndrome okanye toxic epidermal necrolysis. Unyango ngokuyintloko lukhathalelo oluxhasayo, kwaye i-prognosis yesisombululo esipheleleyo sesi sifo idla ngokugqwesa.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Indoda eneminyaka engama-76 ubudala yeza kwigumbi likaxakeka kuba ulusu lwakhe lwalutshintshile kwezi ntsuku zimbini zidlulileyo. Oogqirha bafumana amabala abomvu kwaye baphakamisa iindawo kwisiqu sakhe kunye neengalo nemilenze. Njengoko ixesha lihamba, la mabala adibana kunye, kwaye wavelisa amaqhuma afana ne-pimple kwiindawo ezibomvu. Uvavanyo lubonise ukubalwa kweeseli ezimhlophe eziphezulu ezinohlobo oluninzi olubizwa ngokuba zii-neutrophils, kunye namanqanaba anyukileyo e- C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
